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Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)

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however, some minerals and vitamins, such as vitamin B12, vitamin D, and magnesium, have been shown to support autophagy, a cellular cleaning process that occurs during fasting

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Levels decline with age, stress and toxin exposure

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