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Wrote the paper: Jiancheng Mou, Lichen Hong

Glutamate is converted to intermediate -ketoglutarate (KG) of the TCA cycle by glutamate dehydrogenase (GDH) or alanine or aspartate aminotransferase (TA)

PI move: Document why decisions were made, not just what happened. 6

It combines two pulse modes in a single system : picosecond pulses (trillionths of a second) and nanosecond pulses (billionths of a second)

Furthermore, heterogeneity in diagnostic criteria across studies makes it challenging to compare outcomes consistently

In this regard, using broad-spectrum PKC inhibitors, it has been shown that PKC blockade upregulated p-AMPK levels, resulting in increased levels of LC3-II formation and p62 degradation indicative of increased autophagy, which resulted in the protection against APAP hepatotoxicity (Saberi et al., 2014), thus complementing the JNK-dependent contribution of PKC in APAP hepatotoxicity described above