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Description
Such advances have contributed markedly to elucidating protein structure, function, and the development of new therapeutics 22,23,24

doi:10.1111/bjh.12041

Workman CD, Thrasher TA

Additionally, for patients with DILI specifically affecting liver cells (hepatocellular DILI), progressively worsening jaundice should also raise concerns and prompt evaluation for a potential liver transplant by a specialized center [130]

Nature 487 , 505509 (2012)

Depending on the specific context, reactive gliosis can be either beneficialpromoting improved functional outcomesor detrimental, leading to maladaptive impairments or neurodegeneration 377