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Rozen at UT Southwestern Medical Center.

DDR1 activation in macrophage promotes IPF by regulating NLRP3 inflammasome and macrophage reaction

Dickinson DA

37 A preliminary study has reported that the mSHMT enzyme allows for functional redundancy in cases where activity of the cSHMT enzyme is inhibited, and is up-regulated in cells lacking cSHMT during DNA replication and repair cell phases

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These unique mechanisms necessitate the adoption of strategies different from those for oncology ADCs when developing ADCs for autoimmune diseases, including more stable molecular designs, lower immunogenicity, multi-target coverage, and personalized treatment regimens