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Ferritin, as a central regulator of intracellular iron, has therefore emerged as a potential therapeutic vulnerability across various malignancies

J Transl Med 23 , 52 (2025)

Therefore, it is necessary to conduct a thorough analysis of other pathways involved in mediating disulfidptosis

Nrf2 is an important component of the cellular defense against various exogenous and endogenous stresses that can be activated in response to a series of oxidative and electrophilic stimulations (Kensler et al., 2007)

Indeed, glutathione concentrations as low as 1 mM completely negate the mutagenicity of MA and EA in the L5178Y/TK +/ mouse lymphoma mutagenicity test up to the highest concentrations of the two acrylates tested, 35 g/ml, a higher concentration than that previously found to be mutagenic in this test (14 g MA/ml and 20 g EA/ml)