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In the field of delivery technology, targeting the unique joint anatomy and pathological environment of OA, developing biodegradable sustained-release carriers such as smart responsive nanogels, porous microspheres, or tissue engineering scaffolds is key to achieving long-term and controlled release of GPX4 genes, regulatory miRNAs or ASOs, or small molecule ferroptosis inhibitors at the lesion site (Wang Y

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Timmerman et al (45) identified a subtype of TNBC by evaluating the functional metabolic profiles of breast cell lines, which demonstrated that xCT expression levels are upregulated in one-third of TNBC cases