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Second, a toxicology review to certify the product formulation

USEPA (USEPA 2013b) reported using this approach because basing the inhalation unit risk on one tumor site may underestimate the carcinogenic potential of 1,4-dioxane. Dividing the benchmark response (10%) by the BMCL 10 (19.5 mg/m 3 or 19,500 g/m 3 ) yields an inhalation unit risk (IUR) of 5 x 10 -6 (g/m 3 ) -1

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Endocrine disruption, bioaccumulation, acute/chronic toxicity, and possible antibiotic resistance are the main consequences (Halden, 2014)

Moreover, the less severe skeletal defects observed in the Cart igf-1r mutants compared to the global knockouts indicates that other cells such as osteoblasts (Zhang et al., 2002), osteoclasts (Wang et al., 2006a), and osteocytes (Reijnders et al., 2007), also contribute to normal skeletal development