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Sarrafchi A, Bahmani M, Shirzad H, Rafieian-Kopaei M

These changes also enhance cytotoxic selectivity 18 , with BHMC demonstrating 35-fold greater cytotoxicity against HepG2 hepatocellular carcinoma cells compared to curcumin, accompanied by pronounced cell shrinkage and reduced viable cell counts 19

The effect may diminish the chronic use of nonsteroidal anti-inflammatory drugs [220]

These effects may be attributed to butyrates ability to regulate gene expression as an epigenetic modulator and trigger cellular responses as a signalling molecule

However, there are potential side effects, which are mild and temporary

17 In this paper, we present clinical, biochemical, ultrastructural, and molecular data for five new patients with the dermatosparaxis type of EDS