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When released to the circulation, the bone-derived FGF23 binds to its receptor in epithelial cells of the proximal tubules of the kidney leading to decreased expression the type II sodium-phosphate co-transporters, NPT2a (encoded by the SLC34A1 gene) and NPT2c (encoded by the SLC34A3 gene)

doi: 10.3390/nu14163371

Influence of age on the passage of paraquat through the blood-brain barrier in rats: a distribution and pathological examination

4 (2018): 447459.e4

7 mg/Kgbw and 647.1-1,094.8 mg/Kgbw, respectively (96)

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