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The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition , 19(8), 969988

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For instance, mephedrone increases both dopamine and serotonin release, whereas -PVP primarily targets dopamine and norepinephrine transporters ( 4.2 Oxidative stress and mitochondrial dysfunction The excessive release of monoamines promotes ROS formation through the auto-oxidation of dopamine and norepinephrine

This is due to a favorable electrostatic attraction that induces tight junction opening, resulting in enhanced paracellular transport of ions, macromolecules, and hydrophilic drugs across cell barriers, and importantly, improves the BBB penetration of drug-loaded nanoparticles via adsorptive-mediated endocytosis (Roney et al., 2005