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Celiac plexus block (in the abdomen): Relieves pain commonly caused by cancer, chronic pancreatitis, and other conditions when injected into the bundle of nerves that surrounds the aorta, the main artery to the abdomen

Injecting in a post-absorptive state keeps the signaling environment cleaner and consistent across all 10 doses

Its dramatic age-related decline is significant: plasma concentrations average 200 ng/mL at age 20 but typically plummet to 80 ng/mL by age 60a 60% reduction correlating with visible aging and reduced healing capacity

Cardiovasc Toxicol

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Some patients develop predominantly neurological features with minimal anaemia, whilst others present with severe anaemia but few neurological signs