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By degrading GSH, CHAC1 perturbs redox homeostasis and can effectively blunt the NRF2-driven cytoprotective response

Special Considerations People with asthma should be particularly cautious, as inhaled glutathione has been associated with bronchospasm in some individuals

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Development of kidney disease is associated with the enzyme myeloperoxidase (MPO), abundant in neutrophils catalyzing the transformation of hydrogen peroxide (H 2 O 2 ) to hypochlorous acid (HOCl), a powerful oxidizing cytotoxic agent, according to the reaction HOCl has been found to be responsible for renal dysfunction among obese children

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Perou C.M., Sorlie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Rees C.A., Pollack J.R., Ross D.T., Johnsen H., Akslen L.A., et al

DAMP signals are likely to stimulate the apoptotic and necrotic pathways [314]