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Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein

MTOR and GAPDH are shown as examples of common essential genes

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Activating pathways for creation of NADPH has been shown to protect RPE cells from oxidative damage 74 , and our findings indicate that for developing mouse retinas with RP in which all rods have been lost a possible intervention strategy would be to stimulate synthesis of NADPH