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However, butyrates undergo phase II metabolism due to the carboxylic acid group, leading to rapid elimination and reduced therapeutic efficacy

Ke, X., Zhang, R., Li, P., Zuo, L., Wang, M., Yang, J., & Wang, J

Saz-Lara A

Prodrugs exhibit low toxicity in normal tissues and can be converted into highly toxic primitive forms in tumor tissues [5,6,7].This design allows prodrugs to be converted into active drugs by natural processes such as enzyme reactions, pH changes, or light exposure after they enter the body and reach a specific site

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

Kumar A., Tikoo S., Maity S., Sengupta S., Sengupta S., Kaur A., and Bachhawat A.K