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( Anesthesiology, 2025 ) report that in patients undergoing distal radius surgery with a supraclavicular brachial plexus nerve block, intravenous dexamethasone alone prolongs sensory block duration by ~4.5 hours and reduces rebound pain and 24-hour opioid consumption compared with control, but adding perineural dexamethasone provides no additional or synergistic benefit

However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]

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Visible white patches, discolouration and depigmentation on the skin, vitiligo has been a subject of medical curiosity and emotional concern

10.1016/j.ejcsup.2013.07.016 29
