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The controlled injury itself triggers wound healing responses

The primary function of the pro-inflammatory responders is to trigger an inflammatory phase to fight any possible bacterial invasion that may have taken place

Finally, we should emphasize the rapid presentation of all of these effects

They also showed that intra-tumoral expression of cytokines of the IL-12 family and IFN- (which are caused by induction Th1 and lead to inhibition of tumor growth) diminished

Investigators tapered or paused doses if intolerance developed (57.4% maintained maximum dose at week 68

Management: Start with lower doses and titrate slowly