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Addressing excitotoxicity at the subcellular level mirrors a regulatory approach that spans from the microscopic to the macroscopic domain, thereby conferring a degree of therapeutic relevance

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However, based on structural similarities to other flavonoids such as apigenin and naringenin, which are known to act as positive allosteric modulators of GABA-A receptors 56 , it is plausible that sakuranetin may also interact with GABA-A receptor subunits, possibly at the benzodiazepine binding site