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These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +

From high anxiety trait to depression: a neurocognitive hypothesis

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Importantly, in HD-resistant cells, c-MYC expression is maintained and unresponsive to HD androgens (Fig

A melting curve analysis was performed following amplification to guarantee the absence of primer dimers and other nonspecific products

Andersen, T