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Its main metabolite, DM-6705 (M1), accounts for 13%18% of total plasma exposure and has been associated with QT prolongation

Another double-blind randomized controlled trial of 20 patients undergoing surgery for abdominal aortic aneurysm reported that N-acetylcysteine was associated with anticoagulant and platelet-inhibiting properties, with decreased prothrombin time and prolonged coagulation time (33)

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Statistical analyses were performed using Statsoft Statistica v.13 software (Tibco, Palo Alto, CA, USA)

Haeusler et al., 2014

MacFarlane, A