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Iron overload induces ferroptosis by activating Piezo1, a pressure-sensitive calcium channel in chondrocytes, leading to subsequent calcium inflow, which could be exacerbated by conditional GPX4 knockout in cartilage

doi: 10.1016/j.cyto.2013.04.005 65 Bermejo BenitoPDaz LanzaAMSilvn SenAMDe Santos GalindezJFernandez MatellanoLSanz GmezAet al

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Studies using gene array analysis have shown shifts in expression patterns affecting NF-B pathways, growth factor receptors, and genes encoding structural proteins

Arthroplasty 1 (1), 4

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