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It may additionally influence bone metabolism through immune system modulationvia the secretion of microbial metabolites that interact with immune cells (e.g., T cells, B cells), activate the intestinal mucosal immune response, and induce the production of pro- or anti-inflammatory mediators and cytokines involved in the regulation of bone remodeling (210)

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The findings underscore the promise of this DC vaccine as a cornerstone for advancing and enhancing PCa immunotherapy (Bakhshi et al., 2023)

Key influencing factors include the conditioning regimen, the stem cell source, and strategies for T-cell depletion (49)