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The authors proposed using aspartame with care, but they also called for further research to confirm a link

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[link] Foulquier S, Daskalooulos EP, Lluri G, Hermans KCM, Deb A, Blankesteijn WM, "WNT Signaling in Cardiac and Vascular Disease", Pharmacological Reviews 70 (1): 68-141 (2018)

C-Met is the target gene of multiple miRNAs

We found that HG exposure delayed wound healing in ARPE-19 cells and increased intracellular levels of reactive oxygen species (ROS), while decreasing antioxidant gene expression