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These studies were deemed insufficient to warrant changes because they: (1) relied on mothers self-reported APAP usage, (2) lacked precise quantification of APAP dosage, and (3) frequently utilized questionnaire-based methodologies

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Collectively, these findings indicate that Kla is dynamically regulated to reprogram metabolic pathways in response to cellular metabolic changes and specific metabolic needs

Pierce BCA protein assay kit was applied to measure the total protein concentration of cell lysates