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The final metabolite of beta-oxidation is acetyl-CoA, which can enter the tricarboxylic acid cycle for ATP production

Eur J Clin Pharmacol 1979 Aug

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Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

Thiamine deficiency in causes neurological injury leading to the Wernicke/Korsakoff syndrome ( FIGURE 2 via effects on homocysteine/methionine metabolism as well as DNA methylation

However, whether OS precedes the onset of BIR or vice versa is still under evaluation in AD, and the exact molecular mechanisms underlying the development of BIR have not been completely elucidated