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Oxaliplatin-induced peripheral neuropathy is divided into two kinds: the acute typeis characterized by cold hyperalgesia or allodynia right after treatment, often transiently, and the chronic type results in hardly reversible neuronal damage caused by continuous treatment [10]

K., Gough, L

To address this, the problem formulation (2) needs to be extended and transformed into an optimal control problem

Dong Z, Feng L, Chao Y, Hao Y, Chen M, Gong F, et al

To be specific, BRAF-targeted inhibitors would downregulate the expressions of sprouty RTK signaling antagonist 2/4 (SPRY2/4) and dual-specificity phosphatases (DUSPs), which leads to the relief of the feedback suppression on Ras and reactivation of the ERK signaling, thus rendering the treatment resistance

doi: 10.3389/fendo.2021.678055 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Zhao X, Wang M, Wen Z, et al
