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In a study of adjunctive therapy for complex partial seizures in which patients were receiving either carbamazepine or phenytoin in addition to valproate, no adjustment of carbamazepine or phenytoin dosage was needed [see Clinical Studies(14.3)]

An addition of ointment-based supplements to hypo-osmotic eye drops could provide longer-lasting lubrication, reducing the risk of their rapid removal by blinking

Therefore, on an individual basis, the specific mutation cannot be used to accurately predict the clinical course, severity of symptoms, or to guide therapies

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