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These approaches included anti-IGF-1R monoclonal antibodies (mAbs), IGF-1R tyrosine kinase inhibitors (TKIs), IGF-1/2 blocking mAbs, IGF ligand-TRAPs, recombinant IGFBPs and pregnancy-associated plasma protein-A (PAPP-A) inhibition [54,55]

[2], [4] Retro-inverso peptides (also referred to as D-retro-inverso or DRI peptides) are specially engineered molecules in which the amino acid sequence is reversed and composed of D-amino acids, which are mirror images of the naturally occurring L-amino acids

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P = .001), but no difference was observed between the combined therapy and semaglutide groups

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