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and (iii) inhibition of essential processes such as DNA and protein synthesis, which are critical for bacterial growth and survival (Figure 4)

Shc also activates the MAPK/ERK pathway, which requires the attachment of FRS2 (adaptor protein) at the Tyr515 residue or the activity of the TrkB-interacting protein Kidins220 (Kinase D-interacting substrate of 220 kDa)

Aminoglycoside transports into the hair cell via the MET channel, results in cell demise (Sheth et al., 2017

Acknowledgements The present study was supported by the Research Council of Norway [grant number: 214329]

Early detection of pathogen-associated molecular patterns (PAMP) expressed by the virus is sensed and mediated by pattern recognition receptors (PRRs), such as the Toll-like receptor (TLR)-family or RIG-I like receptor