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The transcription factor nuclear factor E2-related factor 2 (Nrf2) is a major regulator responsible for the expression of a series of antioxidant genes involved in antioxidant response pathways, including iron-dependent ROS production, GSH homeostasis, and GPX4 activity (8)

698 Selenium is closely related to GPX4 and protects GPX4 from irreversible inactivation

Deep sleep rebounds to 85 minutes

GAD) uniquely located in neurons

An adequate and hopefully incisive therapeutic action will therefore depend on a finely orchestrated balance between the efficacy of the single treatment for the specific pathogenetic mechanism and the control of potentially noxious interactions among the different therapies

What are the possible future research priorities in diagnosis and treatment
