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Experimental studies show that, like other thiols, common in foods like garlic, NAC's liberated thiol groups can bind to reactive metal ions, including copper and iron, and the heavy metals cadmium, mercury, and lead, forming complexes that the body can more easily excrete

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Curiously, like the livers of Gsr-null mice reported a decade earlier by Rogers and colleagues [110], TrxR1/Gsr-null livers exhibit no detectable GSSG-reductase activity, yet they maintain normal or higher levels of total GSH, of which nearly all is in the reduced form [107, 108]

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It is associated with reactive gliosis, which is characterized by glial hypertrophy, increased expression of the glial-specific intermediate filament protein GFAP (glial fibrillary acidic protein), and microglial activation (Cederberg and Siesjo, 2010