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EV-QuerCar demonstrated a PDI of 0.16 0.04, a zeta potential of -21.68 1.07 mV, a DL (w/w) of 5.11 0.22%, and an EE (w/w) of 90.07 3.67%

55 S34S35

The signaling pathways include PI3K/Akt, Nrf2, and the mitochondrial regulators that contribute to such neuroprotective effects like enhanced performance of the brain, reduced cell death, and increased neuronal survival

Fabregat, I., Revilla, E., & Machado, A

& Kuchel, O

Studies from this group support that Pb can disrupt the brain export of A leading to its accumulation and plaques formation (Behl et al., Exposure to Pb during development is a good example of an environmental contaminant as a risk factor to promote neurodegenerative diseases such as AD, supporting the hypothesis that many adult diseases have a fetal origin (FeBAD) (Basha et al., APP mRNA expression as well as in the activity of the transcription factor Sp1 (one of the regulators of APP ) in the cortex of neonates, and after 20 months of Pb exposure had ceased