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Finally, we address key translational challenges, including dosing constraints, compensatory mechanisms, and SLC6 family selectivity, while highlighting the potential of structure-guided design to refine GlyT1-targeted therapies.
Pal-GHK, also referred to as Palmitoyl Tripeptide-1 and Palmitoyl Oligopeptide, is a synthetic peptide composed of a fatty acid (palmitoyl) covalently linked to a tripeptide sequence (glycine-histidine-lysine).
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