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Contribution of nrf2 modulation to the mechanism of action of analgesic and anti-inflammatory drugs in pre-clinical and clinical stages

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J Immunol (2008) 180:447686.10.4049/jimmunol.180.7.4476 22 GerrietsVARathmellJC

Research subjects and clinical patients report: Improved skin elasticity and texture Reduced appearance of fine lines, particularly in sun-damaged skin Improved wound healing speed and quality Hair and nail quality improvements (via similar growth factor pathways) This area is growing rapidly in aesthetic medicine and sits naturally alongside broader anti-aging peptide research

Beyond weight loss, 73.5% of participants achieved hemoglobin A1c levels at or below 6.5%, compared to just 15.9% in the placebo group