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Crosslinking of the NTD with pacSph (+UV/UV = 1.73) and, to a lesser extent, with pacCer and pacPC (+UV/UV = 1.40 and 1.12), respectively, was also detected (Fig 5C and D)

Resultant oxidative DNA base lesions have the potential to mutate some genetic material, which would impair the integrity of the genome by preventing transcription and replication and by generating mutagenesis (116)