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B12 overdoses are unusual

NRF2 is considered a central regulator of the cellular responses to changes in redox status but is also an important regulator of an array of processes that includes mitochondrial function, xenobiotic metabolism, carbohydrate, lipid, and iron metabolism, and DNA repair

This raises an intriguing question: is the breach of the bloodbrain barrier in AD simply a byproduct of aging, or does it require the presence of these vascular risk factors

The accumulation of -Syn in excess is known to interact with the mitochondrial outer membrane, resulting in mitochondrial fragmentation (ODonnell et al., 2014

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