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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

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doi:10.1146/annurev-pharmtox-010611-134540, PMID: 23020296 Menzies V, Lyon DE, Archer KJ, Zhou Q, Brumelle J, Jones KH, Gao G, York TP, Jackson-Cook C (2013) Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia

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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Sjogren Y.M., Tomicic S., Lundberg A., Bottcher M.F., Bjorksten B., Sverremark-Ekstrom E., Jenmalm M.C