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None of this is settled science with one clean answer, but the patterns researchers keep finding are why the compound stays popular in lab settings

[DOI] [PMC free article] [PubMed] [Google Scholar] 226.Widocha M, Marcinowicz P, Janoska-Jadzik M, Szulc A

As demonstrated in the small intestine and cultured intestinal cells, DM as well as elevated glucose concentration and AGEs diminish calcium absorption, presumably by downregulating nuclear vitamin D receptor expression and inducing oxidative stress [29, 30, 43, 45, 46]

The SURPASS clinical trial program demonstrated that tirzepatide at its highest dose (15 mg weekly) produced average weight loss of 20-25% of body weight, significantly exceeding the results seen with GLP-1 only agonists

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And I hope that that will be useful in facilitating further discussions about these compounds going forward