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Kennedy GT, Azari FS, Chang A, Bou-Samra P, Desphande C, Predina J, Delikatny EJ, Olson M, Rice DC , Singhal S

Application of metallomic and metabolomic approaches in exposure experiments on laboratory mice for environmental metal toxicity assessment

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However, while excessive peroxidation of lipids is implicated in the pathogenesis of myriads of diseases, the same peroxidation of lipids provides the necessary signalling molecules for the regulation of very important cellular functions that incorporate the balance and regulation of autophagy (Ggotek and Skrzydlewska, 2024) and the decision on survival or cell death (Zheng et al., 2024)

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This result provides evidence that the molecular mechanisms underlying alcohol-induced anxiolytic properties in mice with a manipulated ratio of D1 to D2 receptors are similarly dependent on D1R activation as we found with wildtype mice