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Advances in understanding the effects of erythropoietin on renal fibrosis

Overall they were mild or moderate and only a small proportion of patients had to discontinue the treatment.14 Given these results, mannitol was also tested on non-CF BE and even though the first studies were carried out on small groups of patients, during short periods of time and mostly relating to non-clinical issues, they showed promising results of its use in this patient population.11 An open-label study of mannitol (400mg), carried out on 9 patients with BE, once daily, during a 12-day period documented a highly significant improvement in quality of life, which is assessed by St George's Respiratory Questionnaire (SGRQ), and maintained for 610 days after cessation of treatment

Cell (2012) 149(6):126983

For AD, approved interventions such as cholinesterase inhibitors and NMDA antagonists have modest effects on cognitive decline but are not able to reverse the course of disease [7]

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