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Impact of ADH and ALDH polymorphisms on alcohol metabolism Functional polymorphisms of genes for the alcohol metabolizing enzymes ADH and ALDH2, and differences in the prevalence of the polymorphic alleles in different ethnic populations, have resulted in several studies examining racial and ethnic differences in alcohol metabolism and the influence of ADH1B, ADH1C, and ALDH2 genotypes

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B12 deficiency: The warning sign of low levels in the legs that can occur just at night VITAMIN B12 plays an invaluable role in upholding both the nervous and neurological systems, so depriving the body of the essential vitamin will naturally have severe repercussions in the long run

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