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You still need a caloric deficit

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Pre-existing b12 deficiency or low-normal levels Anyone starting semaglutide with documented b12 deficiency or levels in the low-normal range (200 to 400 pg per milliliter) should receive supplementation

Many patients notice an immediate improvement in skin texture and tone after their first session, with continued enhancement over time

10.1093/hmg/ddx369

Br J Haematol