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Endocr Rev 22(1):5374 Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D (2002) Circulating levels of IGF-1 directly regulate bone growth and density

They are classified into different types, each functioning at specific stages of the cell cycle by activating CDKs

Enhancing anti-tumor immune responses through combination therapies: epigenetic drugs and immune checkpoint inhibitors

Individuals with aldehyde dehydrogenase 2 (ALDH2) deficiency, most prevalent in East Asian populations, accumulate acetaldehyde during alcohol metabolism, producing severe flushing, tachycardia, and nausea even at low intake levels
10.3389/fnana.2014.00155 10 BorovacJ

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