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Bioavailability: NAC has an oral bioavailability of approximately 6-10% due to extensive first-pass metabolism, but the deacetylated cysteine that reaches tissues effectively drives glutathione synthesis [9]

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By Day 45, reduced CYP expression correlated with the emergence of mesenchymal-like cells, although functional hepatocytes remained, as evidenced by continued ALB localization in immunostaining analyses