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Therefore, cancer cells not only use FAO to oxidize fatty acids and to derive energy by mitochondria but they also use acetyl-CoA to endogenously synthesize fatty acids in the cytosol using NADPH as key cofactor for anabolic enzymes (Koundouros and Poulogiannis, 2020)

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Author Contributions Concept and design: Ramy Elantary, Samar Othman Drafting of the manuscript: Ramy Elantary Supervision: Ramy Elantary Critical review of the manuscript for important intellectual content: Samar Othman References 1.Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study