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To address this, scaffold-based splittingpartitioning compounds based on BemisMurcko scaffoldshas become a gold standard for small-molecule drug discovery, as it better simulates real-world scenarios in which a model encounters novel chemotypes 85,86

Recently, a mimetic peptide of TSP-1 called 4N1Ks has been developed as a senolytic therapy and confirm the high interest to investigate CD47 pathway in senescence 48

[DOI] [PMC free article] [PubMed] [Google Scholar] Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Olatunji L.A., Oyeyipo I.P., Micheal O.S., Soladoye A.O