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Assuming that Cys desulfuration only occurs due to reactions catalyzed by CBS and CSE, kinetic simulations reported by Singh et al
It might indicate infection or autoimmunity

Methylmalonic Acid (MMA) Test: High MMA levels suggest B12 deficiency, even if B12 levels are close to normal

The DNA was then enzymatically hydrolyzed with 30 units of micrococcal nuclease and 0.18 units of phosphodiesterase II incubated at 37 C for 5 hours

Kushi et al

Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately In vivo