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Starting with modified furan leads to direct dual-functionalisation of oligonucleotides Showing the broad applicability of this methodology by functionalising eight different primary amine-bearing oligomers (phosphodiester-, phosphorothioate- or peptidic backbone, LNA modifications, internal amines and different terminal amines), we next evaluated the single-site one-step dual-functionalisation of AONs

The accumulation of lipid peroxidation products is closely associated with multiple factors, including genetic variation, denervation, immobilization and remobilization, chronic diseases, nutritional deficiencies, iron overload, alcoholic myopathy, and others