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Fernndez-Ortiz M, Sayed RKA, Fernndez-Martnez J et al (2020) Melatonin/Nrf2/NLRP3 connection in mouse heart mitochondria during aging

doi: 10.3389/fphys.2018.00809

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2019;68:A117A118

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In addition, NAD + production by the NNT enhance SIRT3-mediated deacetylation and loss of NAD + -dependent deacetylase SIRT3 increases the acetylation of IDH2 at K413 and decreases its enzymatic activity by reducing dimerization, thus regulates mitochondrial redox status and promotes cell tumorigenesis in luminal B breast cancer, 137 and B cell malignancies