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Supplementing with riboflavin altered the DNA methylation in people with MTHFR C677T, causing a decrease in methylation of the ACE gene.[ref] Benefits of supplemental riboflavin: Clinical trial data Clinical trials are an excellent way to know if a supplement is effective for most people

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[DOI] [PubMed] [Google Scholar] 289.Sikiric P., Seiwerth S., Aralica G., Perovic D., Staresinic M., Anic T., Gjurasin M., Prkacin I., Separovic J., Stancic-Rokotov D., et al

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doi: 10.1016/0006-3002(59)90605-5

doi: 10.1093/emboj/16.16.4806