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( American Journal of Emergency Medicine, 202 2) emphasize that LAST, though rare in the emergency department, remains potentially fatal and frequently presents first with neurologic symptoms before cardiovascular collapse

Evidences suggest that lipotoxicity mediated by FFAs (52) may induce disruption of ER homeostasis, known as unfolded protein response, an intracellular signaling activated by the accumulation of unfolded/misfolded proteins

A reduction in oxidative stress can be obtained by the assumption of polyphenol-rich juices such as pomegranate and grape juice [70,71,72]

Beyond protein, carbohydrate intake should not be neglected

The combined assessment of oxidative stress markers and micronutrient status may contribute to improved understanding of disease severity patterns and could potentially inform future risk stratification approaches pending further confirmation

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